{
  "search_id": "PM-TB500-20261014-01",
  "searched_at_utc": "2026-10-14",
  "database": "PubMed via NCBI E-utilities",
  "query": "\"TB-500\"[Title/Abstract] OR \"TB500\"[Title/Abstract] OR \"Ac-LKKTETQ\"[Title/Abstract] OR \"LKKTETQ\"[Title/Abstract]",
  "date_filter": "None; database inception to date accessed; ahead-of-print records retained",
  "language_filter": "None",
  "human_filter": "None",
  "search_record_count": 38,
  "records_screened": 38,
  "eligible_direct_human_administration_records_identified": 0,
  "categories": {
    "Review or commentary": 11,
    "Preclinical biology": 7,
    "Analytical or metabolism": 12,
    "Off-topic false positive": 8
  },
  "inclusion_rule": "Original primary report documenting administration of the N-acetylated thymosin beta-4 residues 17-23 fragment Ac-LKKTETQ to human participants. No efficacy threshold required. Any administered human exposure would qualify if identity is established.",
  "screening_level": "Title and full PubMed-returned abstract (37 records with returned abstracts; 1 record without abstract evaluated on title/bibliographic record). This is a targeted evidence audit, not a systematic review and not proof that no unpublished or unindexed study exists.",
  "independent_review": "Screening decisions and headline counts checked in an editorial audit; no clinical review claimed.",
  "excluded_context": "Reviews, in-vitro human-derived matrices/cells, animal work, analytical validation without documented human TB-500 administration, and unrelated abbreviation false positives. Separate full-length thymosin beta-4 evidence was evaluated outside this focused query.",
  "registry_checks": [
    {
      "query": "TB-500",
      "source_url": "https://clinicaltrials.gov/api/v2/studies?query.term=TB-500&format=json&pageSize=100&countTotal=true",
      "checked": "2026-10-14",
      "returned_records": 1
    },
    {
      "query": "Ac-LKKTETQ",
      "source_url": "https://clinicaltrials.gov/api/v2/studies?query.term=Ac-LKKTETQ&format=json&pageSize=100&countTotal=true",
      "checked": "2026-10-14",
      "returned_records": 0
    },
    {
      "query": "LKKTETQ",
      "source_url": "https://clinicaltrials.gov/api/v2/studies?query.term=LKKTETQ&format=json&pageSize=100&countTotal=true",
      "checked": "2026-10-14",
      "returned_records": 0
    }
  ]
}